Epidemiologic Considerations

Epidemiologic considerations in complex disease genetics.

Association studies are becoming an increasingly popular study design not only for testing of candidate genes, but also for genome-wide localization of loci influencing complex disease. This article covers some of the practical concerns in conducting large-scale association studies using epidemiologic samples.

Cardiorenal syndrome type 3: pathophysiologic and epidemiologic considerations.

Cardiorenal syndrome (CRS) type 3 is a subclassification of the CRS whereby an episode of acute kidney injury (AKI) precipitates and contributes to the development of acute cardiac injury. There is limited understanding of the pathophysiologic mechanisms of how AKI contributes to acute cardiac injury and/or dysfunction. An episode of AKI may have effects that depend on the severity and duration...

Epidemiologic studies of human semen quality: considerations for study design.

Few empirical data exist on the characteristics of subjects who provide semen specimens in epidemiologic studies. The objective of this investigation was to determine participation rates and potential biases in a contemporary study of human semen quality. Subjects (n = 268) are a subset of the Child Health and Development Studies. Their mothers enrolled between 1960 and 1963 during pregnancy. A...

Virally associated arthritis 2008: clinical, epidemiologic, and pathophysiologic considerations

Several viruses have been associated with the development of inflammatory arthritis, including the hepatitis viruses (hepatitis B virus and hepatitis C virus), HIV, the parvovirus B19, the human T-cell lymphotropic virus-I, and the alphaviruses. Here, we review the epidemiology, the pathophysiological mechanisms, the pertinent clinical and laboratory findings as well as the principles of therap...

[Methods and considerations in epidemiologic studies of alcoholism].